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. 1975 Dec;124(3):1198–1204. doi: 10.1128/jb.124.3.1198-1204.1975

Interference of dna ts mutations of Escherichia coli with thymineless death.

F Bouvier, N Sicard
PMCID: PMC236027  PMID: 1104577

Abstract

Thermosensitive mutants of Escherichia coli in which deoxyribonucleic acid replication is inhibited at high temperature have been assayed for their response to thymine deprivation at permissive and nonpermissive temperatures. The survival rate of mutants in which initiation of replication is defective at 42 C (dnaA and dnaC-D) is much higher at nonpermissive temperatures than at 32 C. By contrast, thymineless death is not hindered at 42 C in two elongation mutants (dnaE and dnaG). Bacterial strains belonging to the dnaB class exhibit both types of behavior. These results are in accordance with the model linking thymineless death to a disruption of an active replication fork. We discuss the possibility that the dnaB protein takes part in this process of cell decay.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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