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. 2007 Nov 20;97(12):1664–1672. doi: 10.1038/sj.bjc.6604083

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Copyright © 2007 Cancer Research UK

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In vivo tumour growth delay after PHA680632 and irradiation. Left: in vivo experiments in p53−/− HCT116 subcutaneous xenograft. Animals were randomly assigned to control i.p. b.i.d. for 4 days with vehicle (control), PHA-680632 (PHA) 40 mg kg⁻¹ alone b.i.d. for 4 days, IR alone 8 Gy in 1 day or a combination of both (IR began just after the second administration of PHA680632); n=6 per group, mean tumour volumes±s.e.m. are shown. The respective P-values for control vs IR+PHA, PHA vs IR+PHA and IR vs IR+PHA were <0.0001, 0.0003, and 0.0685 respectively. Right diagrammatic representation showing the mechanistic link between Aurora-A, p53, and irradiation.