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. 2007 Jun 19;97(2):253–259. doi: 10.1038/sj.bjc.6603853

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Copyright © 2007 Cancer Research UK

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Percentage decrease in comet tail moment in CLL samples treated with SJG-136±fludarabine for 24 h. The decrease in tail moment reflects an increase in DNA ICL. (A) Ability of SJG-136 to produce DNA ICL in a concentration-dependent manner in the samples tested. (B) The degree of DNA crosslinking correlated with the cytotoxic effects of SJG-136 in vitro. (C) Effect of the combination of SJG-136 and fludarabine resulting in increased DNA crosslinking. (D) Apoptosis was markedly enhanced in a time-dependent manner in samples treated with the combination of SJG-136 and fludarabine when compared to either drug alone. The increase in apoptosis was evident after 12 h (^*P<0.05) and became more marked after 24 and 48 h (^**P<0.0001).