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. 2007 Jun 19;97(2):267–274. doi: 10.1038/sj.bjc.6603852

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Copyright © 2007 Cancer Research UK

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Methylation-dependent regulation of S100 genes in medulloblastoma. (A) The S100 gene cluster at 1q21.3, showing the position (vertical lines) and direction of transcription (>, <) of each gene. Physical positions are based on NCBI Assembly 36 of the human genome (see http://www.ncbi.nlm.nih.gov/). Genes not belonging to the S100 family have been omitted for clarity. (B) Methylation-dependent changes in expression of 16 S100 genes in three medulloblastoma cell lines (MEB-MED8A, D283Med, D425Med), following treatment with the DNA methyltransferase inhibitor, 5-aza-CdR (5 μM, 72 h), determined by analysis using the Affymetrix U133A Human expression array (sequence identities of probes indicated were verified independently). Fold-changes in expression detected by each probe are shown, based on signal intensities assessed by MAS5 software (Affymetrix). Four genes (marked^**) displayed evidence of positive methylation-dependent regulation in ⩾2 cell lines; S100A2, S100A4, S100A6 and S100A10.