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| Antibody | kass (M−1s−1) | kdiss (s−1) | KD (M) |
|---|---|---|---|
| HO-3 | 5.4±1.6 × 104 | 2.7±0.8 × 10−5 | 5.5 × 10−10±0.19 |
| Catumaxomab | 6.1±1.5 × 104 | 3.3±0.3 × 10−5 | 5.6 × 10−10±0.12 |
Interaction between the ECD of native EpCAM and mAb was measured by surface plasmon resonance. Both the parental mAb HO-3 and the trAb variant catumaxomab displayed high-affinity binding with slow off rates.
