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. 2007 Jul 31;97(3):368–377. doi: 10.1038/sj.bjc.6603884

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Copyright © 2007 Cancer Research UK

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c-MET/HGF signal transduction pathways in SCLC. A schematic diagram to illustrate the versatile signalling functions of c-MET/HGF pathway in SCLC regulating various biological functions of the cells, including cytoskeletal functions, cell proliferation and differentiation, survival, and apoptosis is shown. Various potential serine, threonine and tyrosine phosphorylation sites on the signalling phosphoprotein intermediates are included. ⊕=stimulatory; ⊖=inhibitory.