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. 2007 Jun 26;97(3):290–296. doi: 10.1038/sj.bjc.6603872

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Copyright © 2007 Cancer Research UK

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Pharmacokinetic–pharmacodynamic model describing myelosuppression following docetaxel administration (modified from Friberg et al, 2002). k_prol, rate of cell division; k_tr, rate of transit between compartments; k_circ, rate of physiological elimination of circulating cells; Circ₀/Circ, baseline circulating cell counts before drug administration/circulating blood cell count at a given time; Prol, compartment representing progenitor cells; E_drug, cell loss, function proportional to docetaxel concentration in central compartment; MTT, mean transit time through the maturation delay chain.