Table 4. Evaluation of toxicity per patient.
|
Number of patients (N=52)
|
||||||
|---|---|---|---|---|---|---|
| G1 | G2 | G3 | G4 | Toxicity of all gradesa (%) | Toxicity of grade 3–4 (%) | |
| Haematologic toxicity | ||||||
| Anaemia | 8 | 23 | 2 | 1 | 65 | 6 |
| Leukopaenia | 6 | 9 | 3 | — | 35 | 6 |
| Neutropaenia | 7 | 7 | 5 | — | 37 | 10 |
| Thrombocytopaenia | 4 | 2 | — | 2 | 15 | 4 |
| Non-haematologic toxicity | ||||||
| Diarrhoea | 10 | 3 | 7 | — | 39 | 14 |
| Nausea | 17 | 10 | 1 | — | 54 | 2 |
| Vomiting | 8 | 7 | 1 | — | 32 | 2 |
| Mucositis | 15 | 4 | — | — | 37 | — |
| Anorexia | 15 | 20 | 7 | — | 81 | 14 |
| Fatigue | 17 | 13 | 5 | — | 67 | 10 |
| Weight loss | 4 | 3 | — | — | 14 | — |
| Dyspepsia | 15 | 5 | 1 | — | 40 | 2 |
| Skin rash | 8 | 1 | — | — | 17 | — |
| Itching sensation | 12 | 2 | — | — | 27 | — |
| Skin pigmentation | 13 | 1 | — | — | 27 | — |
| Hand – foot syndrome | 2 | 2 | 1 | — | 10 | 2 |
| Abdominal pain | 12 | 2 | — | — | 27 | — |
| Elevated creatinine | 8 | — | — | — | 15 | — |
| Elevated AST/ALT | 10 | 4 | — | — | 27 | — |
| Elevated ALP | 12 | 1 | 2 | 1 | 29 | 6 |
| Hyperbilirubinaemia | 8 | 2 | 1 | 1 | 23 | 4 |
ALP=alkaline phosphatase; ALT=alanine aminotransferase; AST=aspartate aminotransferase; G=Grade.
a
Grading was according to the NCI-Common Toxicity Criteria (Version 2.0).