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. 2007 Aug 14;97(5):678–685. doi: 10.1038/sj.bjc.6603924

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Copyright © 2007 Cancer Research UK

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PTEN probe enumeration and representative dual-colour FISH images are shown for prostate cancer TMA. (A) Digital images of H&E-stained tissue microarray from 107 prostate cancer samples show areas of prostatic adenocarcinoma at low magnification and at × 20 magnification (rectangle) (ScanScope® System, Aperio Technologies, Inc., Vista, CA, USA). (B–D) A magnified H&E area is displayed in a tissue core with accompanying FISH for the PTEN locus. The rectangles show the main FISH image high magnification. (B) The FISH image shows two signals of both red signals (10q23/PTEN locus) and green signals (CEP 10) in most of the nuclei indicating no deletion of PTEN in tumour cells. (C) The FISH image shows tumour cells with single red signal for 10q23/PTEN locus in most of the nuclei and paired green signals for CEP 10 indicating hemizygous deletion of 10q23/PTEN locus in prostate cancer. (D) Representative FISH image of homozygous deletion in prostate cancer shows absence of red signal for 10q23/PTEN locus in most of the nuclei and retained green signals for CEP 10.