Table 1. Genetic networks in the OSCC-derived cell lines.
| Network | Genes in ingenuity networksa | Function | Scoreb |
|---|---|---|---|
| 1 | ATGR1, BDKRB2, CACNA1B, CACNA1C, CACNA1S, CACNB1, CACNG1, CAPN3, CAPN9, CCL2, CCL3, CCL5, CCL7, CCL13, CCL14, CCL15, CCR1, CCR5, CSPG2, CXCL12, DSG2, EGF, EPS15, F10, MYL2, NOS2A, PLA2G10, PLA2G2A, PLCD1, PLEK, PRKCA, RASGRP3, RYR1, TGM1, Grp94 | Cell signalling, cellular function, and maintenance | 71 |
| 2 | AGT1, ANXA1, ATF1, CALML3, CDH11, COPS5, DIABLO, DGS3, FGF10, FPR1, IL11, IR1RN, INHBA, LTBP2, MGP, MMP8, MMP13, MTPN, NOTCH4, PCDH7, RXRA, S100A7, S100A8, S100A9, SAA1, SCARB1, SCUBE1, SCUBE9, SERPINA3, SOD1, TNF, TNFRSF4, TNFRSF9, TPO, UMOD | Lipid metabolism, molecular transport | 20 |
| 3 | AKT1, ATP2A3, BAG3, BBC3, BCL2, CALU, CCL19, CCR7, CDH5, CHGB, CHP, CIB1, CKS2, CLCN3, E2F4, EGF, ETS1, ITPR3, JUB, KRAS, LOCG3928, MIG-6, MYL1, PPP2R3A, PRKCSH, RALGDS, RASGRP1, RBL1, ROCK1, RPS6KB2, RRM1, RRM2, SLC3A2, SLC9A1, TERT | Cancer, cell morphology, cellular compromise | 20 |
| 4 | AHNAK, ATP2A1, BBC3, BGN, BMP1, CANX, CCR6, CDKN1B, CHGA, CHRD, COL5A1, CTSD, CUBN, DDX5, DMP1, FBLN5, FREQ, GFAP, GHR, IER3, IGF1, INPPL1, LGALS3, LOX, LPL, METAP2, MRC1, MTPN, MYC, PLS1, S100A1, S100B, SLC2A4, TLL1 | DNA replication, recombination, and developmental disorder, carbohydrate | 17 |
| 5 | C2, C3, C1QA, C1S, C3AR1, CCL2, DSC1, DSG1, F13A1, HOXD3, IGFBP2, IGFBP5, IL13, ITIH1, JUP, KLK5, MMP2, MMP13, MMP14, MYOD1, PROC, RP6SKA2, S100A4, SERPINA1, SLIT2, SPOK3, TGM2, THBS1, THBS2, TIMP1, TKT, TNNC1, TNNC2, TNNI1, TNNT2 | Organism, injury and abnormalities, cardiovascular system | 17 |
| 6 | ACTN2, ACTN3, CALM1, CASQ1, CD47, CDK6, CDKN1A, CTSK, CXCL12, DCN, ERBB2, ERBB3, ERBB4, EREG, FBLN2, FBN1, GHR, GRB7, GRK1, HAS2, HBEGF, HRC, IFNA2, IL6R, MTPN, MYL9, MYOZ1, PTGS1, RCV1, S100A4, SERPINA3, TGM1, TIMP3, TNC, TRDN | Cellular growth and proliferation, cellular movement, cell death | 17 |
a
Genes in boldface were identified by microarray analysis to be expressed differentially more than two-fold in OSCCs. Other genes were either not on the expression array or not significantly regulated.
b
A score>3 was considered significant.