Table 2. Thirty-five focus genes in network 1.

Affymetrix no.	Gene	Molecular function	Location	Fold changea
217901_at	DSG2	Cell adhesion	Plasma membrane	85.187
200599_s_at	Grp94	Protein folding and sorting, antigen presentation	Plasma membrane	5.479
210037_s_at	NOS2A	Nitric oxide synthase activity	Cytoplasm	5.072
1560074_at	PRKCA	Protein kinase C activity	Cytoplasm	3.781
210641_at	CAPN9	Calpain activity	Unknown	3.003
207162_s_at	CACNA1B	Voltage-gated calcium channel activity	Plasma membrane	2.894
207222_at	PLA2G10	Unknown	Extracellular space	2.749
207225_at	EPS15	Protein binding	Plasma membrane	0.4539
201511_at	BDKRB2	Receptor activity	Plasma membrane	0.4464
205434_s_at	CACNA1C	Voltage-gated calcium channel activity	Plasma membrane	0.4288
218075_at	AGTR1	Receptor activity	Plasma membrane	0.3305
1558450_at	CCR1	Chemokine receptor activity	Plasma membrane	0.2580
207798_s_at	CACNB1	Voltage-gated calcium channel activity	Plasma membrane	0.2346
228767_at	CCL13	Chemokine receptor activity	Extracellular space	0.2200
235070_at	PLEK	Reorganisation	Cytoplasm	0.1697
229819_at	CCR5	Chemokine receptor activity	Plasma membrane	0.1640
228376_at	CCL7	Chemokine receptor activity	Extracellular space	0.1611
218529_at	F10	Peptidase activity	Extracellular space	0.1583
224938_at	PLA2G2A	Protein binding	Extracellular space	0.1339
224939_at	CACNA1S	Voltage-gated calcium channel activity	Plasma membrane	0.1256
214711_at	CCL5	Chemokine receptor activity	Extracellular space	0.1172
214319_at	CCL3	Chemokine receptor activity	Extracellular space	0.1071
1555904_at	CCL15	Chemokine receptor activity	Extracellular space	0.0868
209665_at	RASGRP3	Protein binding	Cytoplasm	0.0810
220781_at	CACNG1	Voltage-gated calcium channel activity	Plasma membrane	0.0744
1553086_at	CSPG2	Unknown	Extracellular space	0.0736
212698_s_at	EGF	Protein binding	Extracellular space	0.0611
226627_at	PLCD1	Unknown	Cytoplasm	0.0381
213666_at	CXCL12	Chemokine receptor activity	Extracellular space	0.0350
211890_x_at	CAPN3	Calpain activity	Cytoplasm	0.0227
216598_s_at	CCL2	Chemokine receptor activity	Extracellular space	0.0198
235340_at	CCL14	Chemokine receptor activity	Extracellular space	0.0165
205485_at	RYR1	Voltage-gated calcium channel activity	Plasma membrane	0.0126
206008_at	TGM1	Cell formation	Plasma membrane	0.0109
209742_s_at	MYL2	Motor activity	Cytoplasm	0.0100

AGTR1=angiotensin II receptor, type 1; BDKRB2=bradykinin receptor B2; CACNA1B=calcium channel, voltage-dependent, L type, α 1B- subunit; CACNA1C=calcium channel, voltage-dependent, L type, α 1C subunit; CACNA1S=calcium channel, voltage-dependent, L type, α 1S subunit; CACNB1=calcium channel, voltage-dependent, β 1 subunit; CACNG1=calcium channel, voltage-dependent, γ subunit 1; CAPN3=calpain 3, (p94); CAPN9=calpain 9; CCL2=chemokine (C-C motif) ligand 2; CCL3=chemokine (C-C motif) ligand 3; CCL5=chemokine (C-C motif) ligand 5; CCL7=chemokine (C-C motif) ligand 7; CCL13=chemokine (C-C motif) ligand 13; CCL14=chemokine (C-C motif) ligand 14; CCL15=chemokine (C-C motif) ligand 15; CCR1chemokine (C-C motif); CCR5=chemokine (C-C motif) receptor 5; CSPG2=chondroitin sulfate proteoglycan 2; CXCL12=chemokine (C-X-C motif) ligand 12; DSG2=desmoglein 2; EGF=epidermal growth factor; EPS15=epidermal growth factor receptor pathway substrate 15; F10=coagulation factor X; Grp94=glucose regulated protein, 94 kDa; MYL2=myosin, light polypeptide 2, regulatory, cardiac, slow; NOS2A=nitric oxide synthase 2A; PLA2G2A=phospholipase A2, group IIA; PLA2G10=phospholipase A2, group X; PLCD1=phospholipase C, delta 1; PLEK=pleckstrin; PRKCA=protein kinase C, α; RASGRP3=RAS guanyl releasing protein 3; RYR1=ryanodine receptor 1; TGM1=transglutaminase 1.

^aFold overexpression for microarray data of OSCC-derived cell lines compared to normal control.