Table 3. Functional characterisation of Ca²⁺-binding protein genes altered expressed in OSCC-derived cell lines.

Relevant function and disease	P-value	Gene, noa
Top-10 functions associated with upregulated genes in OSCC-derived cell lines
Cancerb	1.15E−3 to 4.27E−2	7
Cell death	1.15E−3 to 6.42E−2	4
Cell cycle	1.86E−3 to 6.95E−2	6
Cell-to-cell signalling and interaction	3.94E−3 to 6.16E−2	7
Cell signalling	3.29E−3 to 6.42E−2	6
Molecular transport	4.29E−3 to 7.47E−2	5
Small molecule biochemistry	4.29E−3 to 7.47E−2	9
Nucleic acid metabolism	5.07E−3 to 2.89E−2	4
Cellular growth and proliferation	5.07E−3 to 6.95E−2	3
Cell morphology	8.24E−3 to 6.95E−2	1
Top-10 functions associated with downregulated genes in OSCC-derived cell lines
Cellular movementc	1.60E−13 to 8.53E−3	33
Cellular signalling	1.52E−11 to 8.53E−3	31
Cellular function and maintenance	1.52E−11 to 8.53E−3	16
Small molecule biochemistry	1.52E−11 to 8.53E−3	20
Vitamin and mineral metabolism	1.52E−11 to 7.02E−3	32
Tissue morphology	2.10E−11 to 8.53E−3	33
Molecular transport	2.69E−11 to 8.53E−3	18
Skeletal and vascular system development and function	2.08E−10 to 8.53E−3	21
Cancer	5.13E−9 to 8.53E−3	27
Cell-to-cell signalling and interaction	1.01E−8 to 8.53E−3	26

^aNumber of associated genes.

^bApoptosis, cell movement, proliferation, cell cycle progression, migration, binding quantity of cancer cell line.

^cChemotaxis, migration, cell movement, mobilisation of haematologic cyte.