Table 4. Frequency of EGFR mutations.
|
Tumour tissue
|
Serum
|
|||||
|---|---|---|---|---|---|---|
| + | − | + | − | |||
| (A) Gender and EGFR mutation status | ||||||
| Female | 5 | 9 | 3 | 11 | ||
| Male | 3 | 25 | P=0.092 | 4 | 24 | P=0.669 |
| (B) Histology and EGFR mutation status | ||||||
| Ad | 7 | 24 | 6 | 25 | ||
| Non-Ad | 1 | 10 | P=0.657 | 1 | 10 | P=0.654 |
| (C) Smoking habit and EGFR mutation status | ||||||
| Never | 5 | 9 | 5 | 9 | ||
| Current/former | 3 | 25 | P=0.092 | 2 | 26 | P=0.031 |
| (D) Response to gefitinib | ||||||
| PR | 6 | 4 | 6 | 4 | ||
| SD/PD | 2 | 30 | P<0.001 | 1 | 31 | P<0.001 |
Ad=adenocarcinoma; EGFR=epidermal growth factor receptor; PD=progressive disease; PR=partial response; SD=stable disease; +=mutation positive; −=mutation negative.
P-value: Fisher's exact test.