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. 2007 Oct 2;97(7):934–940. doi: 10.1038/sj.bjc.6603985

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Copyright © 2007 Cancer Research UK

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ZD6474 may not be a substrate of P-gp. (A, B) P-gp-negative MCF-7 and KB cells or P-gp-positive MCF-7/adriamycin (ADR) and KBV200 cells were exposed to ZD6474 for 72 h. (C) MCF-7/ADR cells were treated with ZD6474 in combination with verapamil for 72 h. The cell proliferation was determined by the SRB assay. Each point represents the mean±s.d. for three determinations.