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. 2007 Sep 11;97(7):877–882. doi: 10.1038/sj.bjc.6603966

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Copyright © 2007 Cancer Research UK

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Kaplan–Meier survival curves for the angiogenesis factors, VEGF/PIGF (A), VEGF-D (B), Ang-2 (C), and Tie-2 (D), as well as angio-index (E) and complete remission achievement (F). Each angiogenesis factor was divided into high (dot line) and low (solid line) concentration subgroups based on the distribution of its level. The angio-index was divided into high (dot line) and low (solid line) subgroups with a cut-off value of 50. The P-value was calculated using the log-rank test. The angio-index stands for the formula (Ang-2 × Tie-2)(VEGF/PIGF × VEGF-D).