Table 2. Summary of PK parameters for pemetrexed.
| Pemetrexed expressed as mean±s.d. | ||||
|---|---|---|---|---|
| Dose (mg m−2) | 400 | 500 | 600 | 700 |
| No. of patients | 6 | 5 | 3 | 4 |
| AUC0–∞ (h μg ml−1) | 130±36.4 | 194±75.8 | 187±30.5 | 216±29.3 |
| Cmax (μg ml−1) | 89.1±25.2 | 134±29.4 | 105±10.5 | 131±18.4 |
| CLp (l h−1 m−2) | 3.29±0.96 | 2.59±0.94 | 3.28±0.58 | 3.32±0.48 |
| t(1/2) (h) | 2.57±1.13 | 2.58±1.47 | 1.91±0.49 | 3.00±0.85 |
| Vss (l m−2) | 10.3±3.71 | 7.19±1.68 | 8.07±1.41 | 10.9±2.87 |
AUC=area under the concentration–time curve; CLp=plasma clearance; Cmax=maximum plasma concentration; PK=pharmacokinetic; s.d.=standard deviation; t(1/2)=terminal elimination half-life; Vss=steady-state volume distribution.