Table 3. Summary of PK parameters for vinorelbine.

	Vinorelbine expressed as mean±s.d.
Dose (mg m−2)	15	23	30
No. of patients	7	3	8
AUC0–∞ (h μg ml−1)	0.88±0.60	1.78±0.38	2.04±1.03
Cmax (μg ml−1)	1.48±1.13	2.91±0.14	2.98±1.83
CLp (l h−1 m−2)	27.4±22.9	12.9±0.62	18.7±9.73
t(1/2) (h)	48.3±15.2	36.5±8.21	42.0±11.6
Vss (l m−2)	1067±543	1671±373	1649±1240

AUC=area under the concentration–time curve; CL_p=plasma clearance; C_max=maximum plasma concentration; PK=pharmacokinetic; s.d.=standard deviation; t_(1/2)=terminal elimination half-life; V_ss=steady-state volume distribution.