Table 3. Cox's proportional hazards model (univariate) of relapse of disease.

	Crude model			Adjusted model
	Crude HR	95% CI	P-value	Adjusted HR	95% CI	P-value
CD3 intratumoral 294/118	0.48	[0.27–0.86]	0.01	0.49	[0.28–0.86]	0.01
CD3 peritumoral 795/2043	0.27	[0.13–0.58]	0.0008	0.29	[0.14–0.61]	0.001
CD4 intratumoral 16/213	0.55	[0.31–1.00]	0.05	0.55	[0.31–1.00]	0.05
CD4 peritumoral 106/463	0.62	[0.39–0.99]	0.04	0.61	[0.38–0.98]	0.04
CD8 intratumoral 198/852	0.41	[0.21–0.81]	0.01	0.41	[0.21–0.80]	0.009
CD8 peritumoral 448/1234	0.38	[0.20–0.74]	0.004	0.37	[0.19–0.73]	0.004

HR=hazard ratio.

Cox's proportional hazards regression modeling was performed to determine the association between density of immune cells and relapse of disease. In the model the cell density at the 25 and 75% percentiles was compared, densities shown for each cell type. The model was adjusted for age at diagnosis and FIGO stage.