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. 2007 Sep 18;97(8):1106–1115. doi: 10.1038/sj.bjc.6603984

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Copyright © 2007 Cancer Research UK

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(A and B) Panc-1 cells and IPSCs were transiently transfected with a full-length Runx2 expression vector or an empty control vector. (A) Immunoblot analysis of control-transfected (−) and Runx2 transfected (+) cells was carried out as described in the Patients and Methods section. An ERK2 antibody was used as a loading control. (B) MMP1 levels in Runx2 transfected Panc-1 cells and IPSCs were determined using an ELISA assay and are presented as mean±s.e.m. (n=3) compared to control transfected cells. (C and D) The effects of Runx2 silencing (left panel) and Runx2 overexpression (right panel) on cell growth (C) and cell invasion (D) were determined as described in the Patients and Methods section and are presented as mean±s.e.m. (n=3) compared to the respective controls (^*P<0.05; ^**P<0.005).