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. 2006 Jun 6;95(1):75–79. doi: 10.1038/sj.bjc.6603209

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Copyright © 2006 Cancer Research UK

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(A–D) Immunohistochemical staining for VEGF-C and VEGFR-3. (A) In normal lung tissue, VEGF-C was observed in macrophages (arrow). (B) In tumor tissue, VEGF-C was mainly observed in the cytoplasm of the cancer cells and macrophages infiltrated into the stromal tissues. (C) In normal lung tissue, VEGFR-3 was observed in alveolar type II cells and macrophages. (D) In tumour tissue, VEGFR-3 immunoreactivity was present in the cytoplasm of cancer cells, macrophages and endothelial cells of lymphatic vessels in the stroma surrounding the cancer cells (arrows).