Table 2. First-line chemotherapy.

Schedule	5FU administration	No. of patients
Bolus FUFOL	Bolus	22
LV5FU2	Bolus+infusional	31
5FU continuous infusion	Infusional	49
FOLFOX2	Infusional	25
FOLFOX4	Bolus+infusional	61
FOLFOX6	Bolus+infusional	78
FOLFIRI	Bolus+infusional	41
Chronomodulated FF	Infusional	110
Chronomodulated FFL	Infusional	186
Various bolus	Bolus	18
Various infusional	Infusional	10

LV5FU2: folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d

FOLFOX2: oxaliplatin 100 mg sqm⁻¹ d1; folinic acid 300 mg sqm day⁻¹ in 2 h infusion; 5FU 1500–1800 mg sqm day⁻¹ in 22 h infusion d1-2q14d

FOLFOX4: oxaliplatin 85 mg sqm⁻¹ d1; folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d

FOLFOX6: oxaliplatin 100 mg sqm d1; folinic acid 200 mg sqm⁻¹ 2 h infusion; 5FU 400 mg sqm⁻¹ bolus; 5FU 2400–3000 mg sqm⁻¹ 46 h infusion

FOLFIRI: irinotecan 180 mg sqm⁻¹ d1; folinic acid 200 mg sqm day⁻¹ 2 h infusion; 5FU 400 mg sqm day⁻¹ bolus; 5FU 600 mg sqm day⁻¹ 22 h infusion d1-2q14d

Chronomodulated FF: folinic acid 300 mg sqm day⁻¹; 5FU 700–1000 mg sqm day⁻¹ d1-4q14d

Chronomodulated FFL: oxaliplatin 25 mg sqm day⁻¹; folinic acid 300 mg sqm day⁻¹; 5FU 700–1000 mg sqm day⁻¹ d1-4q14d.