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. 2006 May 30;95(1):1–5. doi: 10.1038/sj.bjc.6603201

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Copyright © 2006 Cancer Research UK

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A representation of HIF-1's effects on radiosensitivity for a HIF-1-expressing tumour cell (blue), a non-HIF-1-expressing tumour cell (green), and a tumour vessel (red). Dashed arrows depict the normal effects of ionising radiation. Dotted arrows show HIF-1-mediated pathways that sensitise tumours to radiation. Solid arrows show HIF-1-mediated pathways that protect tumours from radiation, whose blockade might radiosensitise tumours. ‘VEGF’ symbolises the proangiogenic pathway, ‘p21’ the mitotic pathway, ‘p-p53’ the apoptotic pathway, and ‘ATP’ the metabolic pathway. Note that in this schematic, non-HIF-1-expressing cells are still radiosensitised by HIF-1 blockade.