Table 2. Results of the mixed model analysis.

Parameter	Parameter estimate	s.e.	d.f.	t-value	P-value
Intercept	0.008871	0.3196	97	0.03	0.9779
Age	0.0239	0.006946	862	3.44	0.0006
Treatment response	0.4063	0.05521	862	7.36	<0.0001
Disease progression	−1.1477	0.1031	862	−11.14	<0.0001
Febrile neutropenia	−0.6603	0.08501	862	−7.77	<0.0001
Diarrhoea and vomiting	−0.4629	0.09929	862	−4.66	<0.0001
Hand-foot syndrome	−0.5184	0.09929	862	−5.22	<0.0001
Stomatitis	−0.6634	0.09929	862	−6.68	<0.0001
Fatigue	−0.5142	0.09929	862	−5.18	<0.0001
Hair loss	−0.5086	0.09929	862	−5.12	<0.0001

d.f.=degrees of freedom; s.e.=standard error.

The analysis included 969 observations.