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| Dose (mg m−2) | Number of patients | DLTs (n) |
|---|---|---|
| 300 | 3 | None |
| 500 | 3 | None |
| 600 | 3 | None |
| 700 | 6 | G3 ALT elevation (1) |
| 800 | 3 | None |
| 900 | 4a | None |
| 1000 | 3 | None |
| 1200 | 6 | G3 infection (1); G3 rash (1) |
ALT=alanine transaminase; DLT=dose-limiting toxicity; G3=grade 3.
One patient was excluded for DLT analysis because of grade 3 hyperglycemia at the beginning of the study.
