Table 4. Relationships between intronic SNPs and drug sensitivity in the cell lines of the NCI-60 panel.
|
Top1 inhibitors (18)
|
Antifolates (11)
|
Taxanes (13)
|
|||||
|---|---|---|---|---|---|---|---|
| IC50 ratio | P-value | IC50 ratio | P-value | IC50 ratio | P-value | ||
| Intron 2a | HT vs W | 1.16 | 0.022 | 2.22 | 8.0 × 10−7 | 1.90 | 1.9 × 10−11 |
| Intron 8a | HT vs W | 1.25 | 6.8 × 10−5 | 2.69 | 5.7 × 10−8 | 2.12 | 1.5 × 10−12 |
| Intron 3 | V vs W | 1.85 | 5.7 × 10−8 | 1.39 | 0.86 | 0.46 | 2.8 × 10−9 |
| V vs HT | 1.83 | 1.1 × 10−7 | 0.79 | 0.037 | 0.34 | 2.1 × 10−11 | |
| Introns 6 and 17b | V vs W | 2.01 | 1.0 × 10−8 | 2.21 | 0.064 | 0.69 | 2.3 × 10−5 |
| V vs HT | 1.84 | 5.3 × 10−7 | 1.32 | 0.930 | 0.50 | 1.5 × 10−8 | |
| Allele A | Pres. vs Abs. | 1.91 | 6.0 × 10−9 | 1.69 | 0.272 | 0.58 | 1.8 × 10−9 |
| Allele B | Abs. vs Pres. | 1.16 | 0.006 | 2.72 | 8.1 × 10−7 | 2.21 | 2.6 × 10−12 |
| Allele C | Abs. vs Pres. | 0.70 | 5.0 × 10−10 | 0.39 | 4.4 × 10−8 | 0.58 | 1.0 × 10−10 |
Abbreviations: Abs., absent; HT, heterozygous; Pres., present; V, variant; W: wild-type.
a
Due to the small number (three) of homozygous variants for these variations, comparisons of their IC50s with wild-type and heterozygous samples were not made.
b
All cell lines presented the same variations of introns 6 and 17.