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. 2006 Sep 5;95(7):921–927. doi: 10.1038/sj.bjc.6603349

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Copyright © 2006 Cancer Research UK

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Mean score of hnRNP K in normal colon, primary tumour and metastatic tissues. (A) Total mean scores showed that there was a significant increase in hnRNP K expression when comparing normal colon to primary colorectal cancer (P<0.001). Subsequently mean scores were evaluated based on cellular localisation, nuclear (B) and cytoplasm (C). (B) As tumour stage progressed hnRNP K nuclear expression significantly decreased (normal to tumour P<0.001 and tumour to metastasis P=0.006). (C) No hnRNP K expression was observed in the cytoplasm of normal tissue but there was a significant increase in cytoplasmic immunoreactivity (P<0.001) in primary tumours. No difference was observed in mean hnRNP K cytoplasmic score for the tumour to metastasis transition.