. 2006 Sep 12;95(7):822–828. doi: 10.1038/sj.bjc.6603345

Table 3. Pharmacokinetic parameters of patients treated with 100–260 mg m⁻² SPI-77 i.v. during days 1–22.

	AUC_1–22 (h μg ml⁻¹)		Clearance (l h⁻¹)		V_d (l)		Half-life (h)
Dose SPI-77 (mg m⁻²)	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.
100	8233	2369	0.024	0.01	3.21	1.44	99.28	19.44
200	198 22	6186	0.019	0.002	3.00	0.7	120.83	32.31
260	227 29	4013	0.022	0.004	3.2	0.06	103.95	17.04

AUC=area under the curve; i.v.=intravenous; s.d.=standard deviation; V_d=volume of distribution.

Table 3. Pharmacokinetic parameters of patients treated with 100–260 mg m−2 SPI-77 i.v. during days 1–22.