Table 3. Pharmacokinetic parameters of patients treated with 100–260 mg m−2 SPI-77 i.v. during days 1–22.
AUC1–22 (h μg ml−1)
|
Clearance (l h−1)
|
Vd (l)
|
Half-life (h)
|
|||||
---|---|---|---|---|---|---|---|---|
Dose SPI-77 (mg m−2) | Mean | s.d. | Mean | s.d. | Mean | s.d. | Mean | s.d. |
100 | 8233 | 2369 | 0.024 | 0.01 | 3.21 | 1.44 | 99.28 | 19.44 |
200 | 198 22 | 6186 | 0.019 | 0.002 | 3.00 | 0.7 | 120.83 | 32.31 |
260 | 227 29 | 4013 | 0.022 | 0.004 | 3.2 | 0.06 | 103.95 | 17.04 |
AUC=area under the curve; i.v.=intravenous; s.d.=standard deviation; Vd=volume of distribution.