Table 1. Peptide sequences from BMI-1 and EZH2 predicted to bind HLA class I molecules.
HLA class I restriction element | BMI-1 a | Amino-acid position | EZH2b | Amino-acid position |
---|---|---|---|---|
A0201 | TLQDIVYKL | 74–82 | YMCSFLFNL | 666–674 |
CLPSPSTPV | 271–279 | SQADALKYV | 734–742 | |
B2702/05 | VRYLETSKY | 44–52 | KRFRRADEV | 30–38 |
KRYLRCPAA | 161–169 | YRYSQADAL | 731–739 | |
B4403 | YEEEPLKDY | 195–203 | EELFVDYRY | 725–733 |
KEEVNDKRY | 155–163 | KESRPPRKF | 210–218 |
Peptides were predicted using the BioInformatics and Molecular Analysis Section (BIMAS) website (Parker et al, 1994).
BMI-1 accession number NM_005180.
EZH2 accession number NM_004456.