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. 2006 Oct 24;95(10):1390–1395. doi: 10.1038/sj.bjc.6603428

Figure 1.

Figure 1

The wave figures of the nucleotide sequence of the EGFR gene with heterozygous mutations obtained by direct sequencing (see ‘Patients and Methods’) are shown. Horizontal arrows in both the sense and the antisense directions are shown to demonstrate the two breakpoints of the deletion. The patients in A, B, and C have inframe deletions in exon 19 (Figure A, E746_A750del; B, E746_T753del insA; C, L747_T751del; D, L858R). The double peaks (vertical arrows) represent the heterozygous missense mutations resulting in an amino acid substitution of L858R in exon 19 (Figure D).