Table 2. Univariate analysis of predictors of DCIS recurrence at 5 years using the log rank test.
| Clinical factor | Non-recurrent (n=94) | Recurrent (n=35) | P-value |
|---|---|---|---|
| HER2 status (%) (n=125) | |||
| Positive (⩾2) | 52 (57.8) | 29 (82.9) | |
| Negative (<2) | 38 (42.2) | 6 (17.1) | 0.01 |
| Ki67 score (%) (n=125) | |||
| <12.2 (median) | 52 (57.8) | 10 (28.6) | |
| ⩾12.2 | 38 (42.2) | 25 (71.4) | 0.006 |
| Activated c-Src (%) (n=129) | |||
| Low | 23 (24.5) | 2 (5.7) | |
| Moderate | 38 (40.4) | 15 (42.9) | |
| High | 33 (35.1) | 18 (51.4) | 0.011 |
| ER status (%) (n=126) | |||
| Positive | 61 (67.0) | 21 (60.0) | |
| Negative | 30 (33.0) | 14 (40.0) | 0.524 |
| Tumour grade (%) (n=128) | |||
| Low | 9 (9.7) | 0 (0.0) | |
| Intermediate | 34 (36.5) | 4 (11.4) | |
| High | 50 (53.8) | 31 (88.6) | 0.0003 |
| Margins (%) (n=129) | |||
| Involved (<1 mm) | 78 (83.0) | 19 (54.3) | |
| Clear (⩾1 mm) | 16 (17.0) | 16 (45.7) | 0.001 |
| Patient age (years) (n=129) (%) | |||
| <50 | 6 (6.4) | 8 (22.9) | |
| ⩾50 | 88 (93.6) | 27 (77.1) | 0.019 |
HER2 positivity, high epithelial proliferation, high levels of total cellular activated c-Src, high tumour nuclear grade, involved margins and young age at presentation were associated with a higher disease recurrence at 5 years.