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. 2006 Oct 31;95(10):1367–1370. doi: 10.1038/sj.bjc.6603453

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Copyright © 2006 Cancer Research UK

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De novo expression of Dsc1 and Dsc3 in sporadic colorectal cancer. Dsc1 (A) and Dsc3 (B) are not expressed in normal colonic epithelial tissue, but exhibit de novo expression in colonic adenocarcinoma (Dsc1, C; Dsc3, D). In (C) and (D) staining is present both at the membrane and in the cell cytoplasm. (E) Dsc1 and Dsc3 are not present in normal colonic epithelium (lane 8), but bands of the expected size (corresponding to the Dsc ‘a’ and ‘b’ proteins) were detected by Western blotting in a subset of tumour samples. Samples in lanes 3–5 were adjudged to be positive for Dsc1 (a and b proteins) and Dsc3 (a and b), while that in lane 7 was adjudged positive for Dsc1 (a and b) alone. Bands corresponding in size to Dsc1b and Dsc3b were also detected in the samples in lanes 1 and 7 respectively. The band in lane 6 (lower panel) is nonspecific. Samples in lanes 1 and 3 showed no change in Dsc2, while those in lanes 4–7 showed a reduction in Dsc2 expression (not shown). The sample in lane 2 was not tested for Dsc2. N, normal; T, tumour. Bar, 50 μm.