Table 2. Association between MUTYH and colorectal cancer: review and meta-analysis of published data.
| Study | No. of cases MM/WM/WW | No. of controls MM/WM/WW | Multiplicative model RR (95% CI) | Dominant model RR (95% CI) | Recessive model RR (95% CI) |
|---|---|---|---|---|---|
| (Croitoru et al, 2004) | 12/29/1197 | 0/21/1234 | 2.6 (1.6, 4.3) | 2.0 (1.2, 3.4) | ∞ (2.84, ∞) |
| (Farrington et al, 2005) | 12/45/2160 | 0/28/1794 | 2.0 (1.3, 3.2) | 1.7 (1.1, 2.6) | ∞ (2.29, ∞) |
| (Peterlongo et al, 2005) | 2/4/549 | 0/7/911 | 1.9 (0.7, 5.2) | 1.4 (0.5, 4.2) | ∞ (0.31, ∞) |
| (Fleischmann et al, 2004) | 2/5/351 | 0/0/97 | 4.1(0.2, 71.9) | 4.2 (0.2, 72.2) | ∞ (0.05, ∞) |
| (Kambara et al, 2004) | 0/2/90 | 0/1/52 | 1.2 (0.1, 12.6) | 1.2 (0.1, 12.4) | NA |
| (Wang et al, 2004) | 2/10/432 | 0/4/309 | 2.5 (0.8, 7.5) | 2.1 (0.7, 6.6) | ∞ (0.13, ∞) |
| (Enholm et al, 2003) | 4/5/994 | 0/0/424 | 11.5 (0.7, 193.1) | 8.1 (0.5, 139.0) | ∞ (0.27, ∞) |
| (Zhou et al, 2005) | 0/6/432 | 0/3/466 | 2.1 (0.5, 8.6) | 2.2 (0.5, 8.6) | NA |
| Current replication study | 5/18/905 | 0/20/825 | 1.3 (0.7, 2.3) | 1.0 (0.6, 1.8) | ∞ (0.84, ∞) |
| Overall estimated effect | 39/124/7110 | 0/84/6112 | 2.0 (1.6, 2.6) | 1.6 (1.3, 2.1) | ∞ (8.63, ∞) |
CI=confidence interval; NA=not available; RR=relative risk.
M vs W allele for the multiplicative model, MM and MW vs WW for the dominant model and MM vs MW and WW for the recessive model. The recessive model RR confidence intervals were estimated using Fisher's exact test.