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. 2006 Jul 11;95(3):322–330. doi: 10.1038/sj.bjc.6603255

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Copyright © 2006 Cancer Research UK

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Typical immunohistochemical staining results of NGF, TrkA, and p75NTR for 109 OESCC patients. Each staining intensity was graded into two groups: (A and D) representative of strong and weak NGF expression, respectively; (B and E) representative of strong and weak TrkA expression, respectively; (C and F) representative of negative and positive expression of p75NTR, respectively. (A–C) are sections of poorly differentiated squamous cell carcinoma. (D–F) are sections of well-differentiated squamous cell carcinoma. Original magnification was × 400. Scale bar is 50 μm. (G) Overall survival of patients classified according to the immunoreactivity of NGF. Overall survival analysis using the Kaplan–Meier method revealed that the survival of patients with tumours strongly expressing NGF was significantly poorer than that of patients with tumours weakly expressing NGF (log-rank P=0.019).