Table 3. OR of HL for alcohol drinking and age groupa.
Controls n=1755 |
All HL, n=224
|
Nodular sclerosis HL, n=137
|
|||||
---|---|---|---|---|---|---|---|
n | n | ORb | 95% CI | n | ORb | 95% CI | |
Subjects overall | |||||||
Never regular drinker | 876 | 141 | 88 | ||||
Ever regular drinker | 866 | 81 | 0.61 | (0.43–0.87) | 47 | 0.58 | (0.37–0.92) |
Beer drinker | 507 | 57 | 0.63 | (0.41–0.94) | 34 | 0.60 | (0.35–1.02) |
Wine drinker | 645 | 43 | 0.57 | (0.37–0.88) | 23 | 0.60 | (0.34–1.06) |
Spirits drinker | 284 | 42 | 0.78 | (0.50–1.22) | 25 | 0.68 | (0.38–1.20) |
Subjects <35 years old | |||||||
Never regular drinker* | 119 | 83 | 61 | ||||
Ever regular drinker | 96 | 40 | 0.63 | (0.37–1.09) | 28 | 0.62 | (0.33–1.16) |
Beer drinker | 69 | 33 | 0.76 | (0.41–1.39) | 23 | 0.78 | (0.38–1.59) |
Wine drinker | 41 | 12 | 0.49 | (0.22–1.10) | 7 | 0.44 | (0.16–1.19) |
Spirits drinker | 46 | 24 | 0.78 | (0.41–1.51) | 17 | 0.70 | (0.33–1.50) |
Monthly consumption (g) | |||||||
⩽66 | 6 | 3 | 0.79 | (0.18–3.51) | 2 | 1.13 | (0.18–7.17) |
>66 and ⩽341 | 13 | 4 | 0.56 | (0.16–2.01) | 2 | 0.46 | (0.09–2.50) |
>341 | 24 | 9 | 0.72 | (0.27–1.89) | 7 | 0.91 | (0.29–2.80) |
P trendc | 0.17 | 0.44 | |||||
Age at start (years) | |||||||
≥18 | 38 | 19 | 0.75 | (0.38–1.47) | 11 | 0.57 | (0.25–1.30) |
≥16 and <18 | 35 | 13 | 0.50 | (0.23–1.12) | 10 | 0.54 | (0.22–1.33) |
<16 | 22 | 6 | 0.46 | (0.17–1.26) | 6 | 0.76 | (0.26–2.22) |
P trendc | 0.52 | 0.64 | |||||
Duration (years) | |||||||
⩽7 | 35 | 15 | 0.57 | (0.27–1.19) | 13 | 0.62 | (0.28–1.39) |
>7 and ⩽13 | 35 | 12 | 0.47 | (0.21–1.05) | 6 | 0.28 | (0.10–0.81) |
>13 | 25 | 11 | 1.01 | (0.40–2.56) | 8 | 1.57 | (0.52–4.75) |
P trendc | 0.03 | 0.18 | |||||
Lifetime consumption (kg) | |||||||
<16 | 27 | 8 | 0.44 | (0.18–1.06) | 4 | 0.29 | (0.09–0.92) |
≥16 and <61 | 31 | 14 | 0.66 | (0.31–1.41) | 10 | 0.69 | (0.29–1.65) |
≥61 | 36 | 16 | 0.76 | (0.35–1.64) | 13 | 0.96 | (0.40–2.33) |
P trendc | 0.07 | 0.16 | |||||
Subjects ≥35 years old | |||||||
Never regular drinker** | 757 | 58 | 27 | ||||
Ever regular drinker | 770 | 41 | 0.58 | (0.35–0.94) | 19 | 0.52 | (0.26–1.04) |
Beer drinker | 438 | 24 | 0.51 | (0.28–0.92) | 11 | 0.42 | (0.18–0.98) |
Wine drinker | 604 | 31 | 0.58 | (0.34–1.01) | 16 | 0.67 | (0.32–1.42) |
Spirits drinker | 238 | 18 | 0.71 | (0.38–1.36) | 8 | 0.57 | (0.23–1.43) |
Monthly consumption (g) | |||||||
⩽215 | 121 | 5 | 0.52 | (0.20–1.38) | 3 | 0.58 | (0.16–2.08) |
>215 and ⩽734 | 249 | 13 | 0.63 | (0.32–1.24) | 7 | 0.64 | (0.25–1.60) |
>734 | 274 | 19 | 0.66 | (0.35–1.26) | 7 | 0.47 | (0.18–1.25) |
P trendc | 0.09 | 0.40 | |||||
Age at start (years) | |||||||
>22 | 216 | 12 | 0.72 | (0.36–1.42) | 7 | 0.82 | (0.33–2.05) |
>18 and ⩽22 | 203 | 7 | 0.44 | (0.19–1.04) | 3 | 0.41 | (0.12–1.48) |
⩽18 | 320 | 22 | 0.63 | (0.34–1.15) | 9 | 0.45 | (0.18–1.10) |
P trendc | 0.88 | 0.31 | |||||
Duration (years) | |||||||
⩽29 | 238 | 20 | 0.53 | (0.29–0.97) | 10 | 0.47 | (0.20–1.11) |
>29 and ⩽44 | 266 | 15 | 0.73 | (0.37–1.44) | 5 | 0.53 | (0.18–1.57) |
>44 | 253 | 6 | 0.51 | (0.19–1.38) | 4 | 0.76 | (0.21–2.77) |
P trendc | 0.60 | 0.40 | |||||
Lifetime consumption (kg) | |||||||
<143 | 221 | 16 | 0.72 | (0.39–1.33) | 9 | 0.76 | (0.33–1.76) |
≥143 and <425 | 259 | 14 | 0.55 | (0.28–1.09) | 5 | 0.38 | (0.13–1.09) |
≥425 | 259 | 11 | 0.50 | (0.23–1.07) | 5 | 0.44 | (0.15–1.33) |
P trendc | 0.07 | 0.23 |
CI=confidence interval; HL=Hodgkin's lymphoma; OR=odds ratio.
Reference category for all alcohol variables among subjects <35 years old.
Reference category for all alcohol variables among subjects ≥35 years old.
Excluding data from Germany.
Adjusted for age, sex, educational level, smoking status and centre.
P trend using ever-regular drinkers only (excludes never-regular drinkers) and adjusted for the other alcohol variables in the table.