Table 4. HHT Pharmacokinetic parameters.

Dose			Cmax day 5 (ng ml−1)		Tmax day 5 (h)		Cmin day 5 (ng ml−1)		Cmin day 9 (ng ml−1)		AUC day 9 (ng h ml−1)		Vdβ/F (l kg−1)		CL/F (l h−1)		T1/2 (h)
mg m−2 day−1	mg	No. Pts	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.	Mean	s.d.
0.5	0.9–1.0	3	10.5	8.8	1.0	0.12	3.4	0.9			169	38	1.52	0.39	5.9	1.60	13.4	3.8
3	4.8–5.4	2	78.0	18.2	0.6	0.53	27.4	27.9	14.7	8.3	441	291	2.54	0.75	14.2	8.77	8.9	3.7
5	7.0–10.0	12	96.1	20.3	0.6	0.43	31.3	16.7	25.6	20.3	909	550	2.02	1.43	11.6	10.4	10.8	3.2
Grand mean																	11.01	3.4*

^**P-value for Kruskall–Wallis test (P=0.52).