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. 2006 Jul 25;95(3):289–297. doi: 10.1038/sj.bjc.6603242

Table 3. Effects of modulation of dCK and hENT on gemcitabine (dFdC, 1 h) and gemcitabine-pemetrexed (MTA) combinations IC50s (nM) in T24 and J82 cells. Values are means±s.d. of at least three separate experiments.

Cell lines Treatments IC50 +Deoxycytidine +Dipyridamole +NBMPR
  dFdC 91.7±5.1 157.7±23.7 4513.4±909.5 7475.3±1337.3
  T24 dFdC-MTA 47.3±5.0 72.3±13.7 78.0±87.3 67.7±9.7
  MTA-dFdC 10.3±2.0 12.6±8.7 49.1±6.2 48.7±6.5  
  dFdC 4366.7±833.3 5863.0±234.5 4959.7±109.1 4476.5±801.3  
J82 dFdC-MTA 83.3±12.0 108.1±7.7 86.7±11.8 85.7±4.3  
  MTA-dFdC 100.0±9.7 111.1±12.3 101.3±2.7 99.7±5.2