Table 3. Health related quality of life, SF-36 scoresa: mean (s.d.).
|
Grampian
|
Wales
|
|||||
|---|---|---|---|---|---|---|
| Time | Nurse counsellor | Geneticist | Difference (95% CI)b | Nurse counsellor | Geneticist | Difference (95% CI)b |
| Physical functioning | ||||||
| Baseline | 88.9 (18.6) | 85.4 (21.8) | 83.5 (21.8) | 88.9 (18.3) | ||
| FU1 | 88.2 (19.1) | 88.6 (18.7) | −0.5 (−3.3 to 2.2) | 84.9 (20.9) | 88.0 (22.5) | 0.3 (−3.7 to 4.3) |
| FU2 | 87.9 (18.5) | 86.4 (21.3) | 0.2 (−2.3 to 2.7) | 84.6 (21.3) | 88.6 (20.1) | −0.5 (−5.5 to 4.5) |
| Social functioning | ||||||
| Baseline | 84.0 (23.4) | 84.6 (22.1) | 77.7 (24.4) | 79.8 (26.2) | ||
| FU1 | 83.4 (23.9) | 85.2 (21.2) | −0.6 (−5.7 to 4.5) | 78.9 (24.8) | 79.9 (25.4) | 0.3 (−4.9 to 5.4) |
| FU2 | 84.7 (21.8) | 87.2 (23.2) | −1.0 (−6.4 to 4.4) | 78.0 (26.9) | 80.1 (26.4) | −1.0 (−7.6 to 5.5) |
| Role physical | ||||||
| Baseline | 87.1 (29.0) | 86.1 (31.3) | 81.6 (33.5) | 84.9 (30.9) | ||
| FU1 | 86.8 (30.2) | 85.1 (32.6) | 5.1 (−1.6 to 11.8)c | 77.4 (37.7) | 82.7 (33.4) | −3.9 (−11.4 to 3.6) |
| FU2 | 86.0 (30.9) | 87.1 (30.3) | 1.3 (−6.1 to 8.7) | 77.5 (37.9) | 74.0 (38.7) | 5.5 (−4.3 to 15.4) |
| Vitality | ||||||
| Baseline | 58.6 (21.3) | 58.5 (23.3) | 53.6 (21.1) | 54.9 (21.3) | ||
| FU1 | 60.8 (21.7) | 61.7 (19.4) | 0.5 (−3.7 to 4.7) | 57.1 (22.3) | 55.7 (20.3) | 2.0 (−2.3 to 6.3) |
| FU2 | 61.6 (20.7) | 63.9 (19.0) | −1.4 (−5.7 to 2.9) | 55.3 (22.5) | 58.3 (21.1) | −1.8 (−7.0 to 3.4) |
| Bodily pain | ||||||
| Baseline | 76.3 (23.9) | 76.6 (25.1) | 72.3 (25.4) | 75.5 (25.0) | ||
| FU1 | 78.6 (24.7) | 77.4 (24.4) | 2.3 (−2.4 to 7.1) | 75.8 (24.6) | 75.8 (26.0) | −0.2 (−5.3 to 4.9) |
| FU2 | 78.2 (24.5) | 76.1 (23.8) | 1.7 (−3.8 to 7.2) | 74.9 (24.9) | 75.2 (19.4) | −0.2 (−6.8 to 6.4) |
| General health | ||||||
| Baseline | 73.5 (19.8) | 73.4 (18.9) | 66.0 (20.6) | 71.2 (20.0) | ||
| FU1 | 75.2 (20.7) | 74.9 (18.4) | 0.8 (−2.5 to 4.0) | 67.9 (21.4) | 69.9 (20.7) | 1.0 (−2.4 to 4.3) |
| FU2 | 75.0 (18.6) | 73.7 (18.5) | 1.7 (−2.0 to 5.4) | 68.6 (21.5) | 72.5 (19.4) | −0.03 (−3.9 to 3.8) |
a
Higher score indicates better health state (range 0–100).
b
Adjusted for baseline.
c
Larger than expected difference due to baseline imbalance of responders at FU1.