Figure 6.

Individual values of biochemical markers of angiogenesis, tumour invasion and bone turnover in the 15 patients participating in the longitudinal evaluation who develop bone metastases during follow-up. For each marker, individual values are shown at the time of diagnosis of primary breast cancer (baseline) and at the time of second sampling before bone metastases was documented by bone scan (follow-up, see Patients and methods). Dotted lines indicate the upper limit of healthy controls (95th percentiles); the percentages represent the proportion of patients with values above the upper limit of healthy controls at baseline and at follow-up.