Table 2. Diagnostic value of biochemical markers to distinguish breast carcinoma patients with bone metastases from those without bone involvement.
| Marker | Cutoff value | AUC | Sensitivity (%) | Specificity (%) | Diagnostic accuracy (%) | 95th Percentile of healthy controls |
|---|---|---|---|---|---|---|
| VEGF (pg/ml) | 478 | 0.768 | 43 | 100 | 78 | 202 |
| TGβ1 (ng/ml) | 41 | 0.511 | 18 | 95 | 65 | 39.8 |
| MMP-2 (ng/ml) | 169 | 0.900 | 83 | 85 | 85 | 174 |
| MMP-7 (ng/ml) | 4.62 | 0.752 | 43 | 98 | 76 | 3.41 |
| MMP-9 (ng/ml) | 376 | 0.702 | 79 | 66 | 71 | 144 |
| TIMP-1 (ng/ml) | 176 | 0.768 | 46 | 91 | 74 | 149 |
| Bone ALP (ng/ml) | 11.5 | 0.858 | 79 | 82 | 81 | 9.6 |
| PINP (ng/ml) | 80 | 0.815 | 46 | 98 | 78 | 79 |
| TRACP 5b (U/l) | 3.05 | 0.856 | 64 | 95 | 83 | 2.87 |
| OPG (pmol/l) | 5.33 | 0.600 | 32 | 84 | 64 | 3.67 |
| CTX (ng/ml) | 0.382 | 0.814 | 95 | 75 | 68 | 0.353 |
| ICTP (μg/l) | 4.47 | 0.903 | 86 | 82 | 83 | 4.25 |
Receiving operating curves (ROC) were generated and the area under the curve (AUC) sensitivity, specificity were determining at the cutoff providing the highest diagnostic accuracy for each individual marker.