Table 2. Reasons for dose reduction.

	Treatment groups
	IG (255 cycles)	G (245 cycles)
	n (%)	n (%)
Dose reduction	34 (13.3)	60 (24.5)
Due to:
Haematologic toxicity	12 (35.3)*	16 (26.7)
Nonhaematologic toxicity	10 (29.4)	8 (13.3)
Haematologic and nonhaematologic toxicity	1 (2.9)	1 (1.7)
Day 8 and/or day 15 treatment not given (for reasons other than toxicity)	10 (29.4)	28 (46.7)†
Other	1 (2.9)	7 (11.7)

^*P<0.001.

^†P 0.002.