Table 3. Adjusted odds ratio (with corresponding 95% confidence limits) of high-risk breast cancer among 11 685 premenopausal and 17 080 postmenopausal women diagnosed with breast cancer in Denmark, 1983–1999.
|
Premenopausal women (N=11 685)
|
Postmenopausal women (N=17 080)
|
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|---|---|---|---|---|
| Odds ratio | 95% confidence limits | Odds ratio | 95% confidence limits | |
| Age | ||||
| –44 years (per year) | 0.95 | 0.93,0.96 | ||
| 45–69 years (per year) | 1.01 | 1.00,1.03 | 0.99 | 0.98,1.00 |
| P-value <0.001 | P-value=0.04 | |||
| Highest attained education | ||||
| Basic school/high school | 1 | 1 | ||
| Vocational training | 0.92 | 0.82,1.04 | 0.92 | 0.84,1.01 |
| Higher education | 0.95 | 0.82,1.09 | 0.83 | 0.73,0.94 |
| Unknown | 0.80 | 0.58,1.11 | 0.90 | 0.78,1.04 |
| P-value=0.37 | P-value=0.019 | |||
| Occupation | ||||
| Higher functionary | 1.00 | 0.79,1.26 | 1.03 | 0.90,1.19 |
| Lower functionary | 1.12 | 0.89,1.40 | 0.98 | 0.85,1.14 |
| Skilled worker | 1.14 | 0.88,1.48 | 1.10 | 0.91,1.34 |
| Unskilled worker | 1.03 | 0.82,1.29 | 1.10 | 0.94,1.28 |
| Unemployed | 1.04 | 0.82,1.31 | 0.97 | 0.87,1.10 |
| Pensioner | 1 | 1 | ||
| P-value=0.58 | P-value=0.64 | |||
| Disposable income a | ||||
| –99 999 | 1.16 | 0.98,1.37 | 1.27 | 1.12,1.44 |
| 100 000–129 999 | 1.05 | 0.91,1.21 | 1.18 | 1.04,1.33 |
| 130 000–164 999 | 1.09 | 0.96,1.25 | 1.12 | 1.00,1.26 |
| 165 000– | 1 | 1 | ||
| P-value=0.30 | P-value=0.003 | |||
| Cohabiting status | ||||
| Living with partner | 1 | 1 | ||
| Single | 0.94 | 0.82,1.07 | 1.01 | 0.92,1.10 |
| P-value=0.35 | P-value=0.88 | |||
| Children living at home b | ||||
| 0 | 1 | 1 | ||
| 1 | 0.94 | 0.83,1.07 | 1.29 | 0.96,1.72 |
| 2–5 | 1.13 | 0.96,1.33 | 0.70 | 0.39,1.25 |
| P-value=0.06 | P-value=0.11 | |||
| Housing status | ||||
| Owner-occupied | 1 | 1 | ||
| Rental | 0.93 | 0.81,1.06 | 0.97 | 0.88,1.07 |
| P-value=0.27 | P-value=0.55 | |||
| Size of dwelling | ||||
| 0–99 m2 | 1 | 1 | ||
| 100–124 m2 | 0.98 | 0.84,1.13 | 1.00 | 0.90,1.12 |
| 125–149 m2 | 0.92 | 0.79,1.08 | 1.01 | 0.88,1.14 |
| 150–m2 | 0.92 | 0.79,1.07 | 0.93 | 0.82,1.05 |
| P-value=0.62 | P-value=0.52 | |||
| Degree of urbanicity | ||||
| Capital area | 0.96 | 0.82,1.13 | 0.92 | 0.81,1.05 |
| Suburban area | 0.93 | 0.81,1.08 | 0.80 | 0.72,0.90 |
| Provincial cities | 1 | 1 | ||
| Rural areas | 1.06 | 0.95,1.18 | 1.13 | 1.02,1.24 |
| P-value=0.38 | P-value <0.001 | |||
| Mammography screening available | ||||
| Not available | 1 | 1 | ||
| Availablec | 0.65 | 0.47,0.90 | 0.54 | 0.49–0.61 |
| P-value=0.009 | P-value <0.001 | |||
| Comorbidity d | ||||
| 0 | 1 | 1 | ||
| 1 | 0.86 | 0.67,1.10 | 0.96 | 0.83,1.10 |
| 2– | 0.94 | 0.55,1.59 | 1.19 | 0.93,1.52 |
| P-value=0.48 | P-value=0.30 | |||
High-risk breast cancer: tumor size >2.0 cm, positive axillary lymph nodes, high histologic grade and estrogen receptor negative; P-values from Wald's test.
Household disposable income in Danish crowns (DKK) after taxation and interest adjusted for number of persons in household.
Children aged 0–17 years.
Mammography screening was offered to all women aged 50–69 years living in Copenhagen municipality from 1991, Frederiksberg municipality from 1992 and Funen County from 1994.
Presence of these disorders as defined in Charlson index was defined as an in- or outpatient contact with one of the below diagnosis from 1978 to half a year prior to the diagnosis of breast cancer; Score 1: myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, connective tissue disease, ulcer disease, mild liver disease, diabetes type1, diabetes type2; Score 2: hemiplegia, moderate to severe renal disease, diabetes with end organ damage type1, diabetes with end organ damage type2; Score 3: moderate to severe liver disease; Score 6: AIDS; All cancer related diagnoses were excluded since first primary cancers only are in DBCG.