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. 2006 Oct 17;95(8):961–965. doi: 10.1038/sj.bjc.6603406

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Copyright © 2006 Cancer Research UK

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NPI-0052- and Bortezomib-induced cell-death signalling pathways. Both NPI-0052 and Bortezomib trigger intrinsic (caspase-9-mediated) and extrinsic (caspase-8-mediated) apoptotic signalling pathways. Deletion of Bax/Bak results in significant loss of response to Bortezomib, but not NPI-0052.