Table 3. Identification of genes that distinguish among benign, borderline and malignant ovarian tumours by prediction analysis of microarrays.
|
PAM Score
|
|||||
|---|---|---|---|---|---|
| Accession no. | Symbol | Gene | Benign | Borderline | Malignant |
| H08561 | IGFBP5 | Insulin-like growth factor binding protein 5 | 0.2760 | 0 | −0.0547 |
| AA977242 | CIRBP | Cold-inducible RNA-binding protein | 0.2298 | 0 | 0 |
| AA459941 | PEG3 | Paternally expressed 3 | 0.2251 | 0 | 0 |
| AA001614 | INSR | Insulin receptor | 0.1515 | 0 | 0 |
| AA424584 | LTBP2 | Latent transforming growth factor beta binding protein 2 | 0.1270 | 0 | 0 |
| AA448277 | FOXO1A | Forkhead box O1A (rhabdomyosarcoma) | 0.1233 | 0 | 0 |
| AA481438 | SERPING1 | Serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1 | 0.1197 | 0 | 0 |
| AA700832 | RBP1 | Retinol binding protein 1, cellular | 0.1105 | 0 | 0 |
| AA481026 | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.1064 | 0 | 0 |
| AA156802 | LAMB2 | Laminin, beta 2 (laminin S) | 0.1022 | 0 | 0 |
| AA056232 | GSTM5 | Glutathione S-transferase M5 | 0.0977 | 0 | 0 |
| AA679454 | STAR | Steroidogenic acute regulatory protein | 0.0815 | 0 | 0 |
| AA682423 | MAOB | Monoamine oxidase B | 0.0663 | 0 | −0.0675 |
| AA398366 | SH3GL1 | SH3-domain GRB2-like 1 | 0.0514 | 0 | 0 |
| N78902 | LEPR | Leptin receptor | 0.0481 | 0 | 0 |
| AA405767 | PAX8 | Paired box gene 8 | 0 | 0 | 0.0471 |
| AA478553 | DCT | Dopachrome tautomerase | 0.0447 | 0 | 0 |
| AA045735 | — | Transcribed sequence with moderate similarity to protein sp:P39195 | 0.0345 | 0 | 0 |
| AA460833 | PGCP | Plasma glutamate carboxypeptidase | 0.0147 | 0 | 0 |
| AA490471 | SPARCL1 | SPARC-like 1 (mast9, hevin, SC-1) | 0 | 0 | −0.0093 |
| W15267 | LRP6 | Low density lipoprotein receptor-related protein 6 | 0 | 0 | −0.008 |
| AA464856 | ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.0036 | 0 | 0 |
| AI934925 | SLC23A1 | Solute carrier family 23 (nucleobase transporters), member 1 | 0 | 0 | 0.0013 |
| R38201 | OPCML | Opioid-binding protein/cell adhesion molecule-like | 0 | 0 | 0.0012 |
| H99676 | COL6A1 | Collagen, type VI, alpha 1 | 0.0005 | 0 | 0 |
The score derived from this analysis using a significance threshold of 3.1 is shown.