Figure 2.

Moxifloxacin enhances the antiproliferative effect of VP-16. Time-dependent studies: THP-1 cells (A) and Jurkat cells (C) were incubated for 24–72 h with 0.5 μg ml⁻¹ VP-16 in the presence or absence of various concentrations of MXF. Cell proliferation was determined by colorimetric MTT assay. Dose-dependent studies: THP-1 cells (B) and Jurkat cells (D) were incubated for 48 h in the presence of the indicated concentrations of VP-16 and MXF. Cell proliferation was determined as described above. Results are expressed as mean±s.e. of four experiments performed in triplicate. ^*P<0.05 cells treated with drugs vs control. ^**P<0.007 for cells treated by VP-16+MXF vs VP-16 alone.