Table 1. Percentage of methylation (NIM) and tumour stage/grade in TCC.
APAF-1
|
DAPK-1
|
|||||
---|---|---|---|---|---|---|
G1/2 | G3 | P-value | G1/2 | G3 | P-value | |
pTa | ||||||
Median | 20 | 53.4 | 34.1 | 3.6 | ||
Mean | 22.7 | 49.6 | 37.2 | 17.6 | ||
STD | 14.7 | 17.8 | 37.1 | 23.5 | ||
n | 14 | 6 | 14 | 6 | ||
P-value | 0.002* | 0.6* | ||||
0.001** | 0.8** | |||||
pT1 | ||||||
Median | 53.5 | 71 | 18.3 | 24 | ||
Mean | 62.8 | 66.4 | 27.4 | 41.3 | ||
STD | 29.7 | 19.4 | 29.1 | 47.9 | ||
n | 10 | 20 | 10 | 20 | ||
P-value | 0.4* | 0.7* | ||||
0.001*** | 0.09*** | |||||
⩾pT2 | ||||||
Median | n.o. | 97.5 | n.o. | 1 | ||
Mean | 94.1 | 15.8 | ||||
STD | 27.1 | 35.4 | ||||
n | 30 | 30 |
NIM=normalised index of methylation; n.o.=not observed; STD=standard deviation; TCC=transitional cell carcinoma.
G1/2 vs G3 tumours.
pTa vs pT1 tumours.
pT1 vs ⩾pT2 tumours.
Normal bladder tissue (n=20): APAF-1 median (0%), mean (7%), STD (17.3%)/DAPK-1 median (0%), mean (5%), STD (15.5%).