Table 2. Toxic effects and number of patients with toxicity according to the dose level of paclitaxel.
| Paclitaxel |
Level 1 (n=3)
|
Level 2 (n=3)
|
Level 3 (n=6)
|
Level 4 (n=5)
|
||||
|---|---|---|---|---|---|---|---|---|
| Grade | 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 |
| Haematological | ||||||||
| Leucopenia | 2 | 0 | 1 | 0 | 3 | 1 | 0 | 0 |
| Neutropenia | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
| Anaemia | 1 | 0 | 2 | 0 | 2 | 1 | 1 | 0 |
| Thrombocytopenia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Non-haematological | ||||||||
| Anorexia | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 1 |
| Nausea | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
| Diarrhoea | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
| Fatigue | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
| Stomatitis | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rash | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Vertigo | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Bilirubin | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| AST/ALT | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| Hyperkalemia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
AST=aspartate aminotransferase; ALT=alanine aminotransferase; n=number of patients.
National Cancer Institute common toxicity criteria (version 2).