Table 2. Toxic effects and number of patients with toxicity according to the dose level of paclitaxel.
Paclitaxel |
Level 1 (n=3)
|
Level 2 (n=3)
|
Level 3 (n=6)
|
Level 4 (n=5)
|
||||
---|---|---|---|---|---|---|---|---|
Grade | 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 |
Haematological | ||||||||
Leucopenia | 2 | 0 | 1 | 0 | 3 | 1 | 0 | 0 |
Neutropenia | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
Anaemia | 1 | 0 | 2 | 0 | 2 | 1 | 1 | 0 |
Thrombocytopenia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Non-haematological | ||||||||
Anorexia | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 1 |
Nausea | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Diarrhoea | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Fatigue | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
Stomatitis | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rash | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Vertigo | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bilirubin | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
AST/ALT | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
Hyperkalemia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
AST=aspartate aminotransferase; ALT=alanine aminotransferase; n=number of patients.
National Cancer Institute common toxicity criteria (version 2).