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. 2006 Jan 24;94(3):398–406. doi: 10.1038/sj.bjc.6602954

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Copyright © 2006 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Combined TRAIL and ATO treatment leads to increased pro-caspase-8 cleavage and activation. Jurkat and K562 cells were treated with TRAIL (50 and 250 ng ml⁻¹, respectively), ATO (500 ng ml⁻¹) or with both for the indicated times. Pro-caspase-8 cleavage (A, B) and IETDase activity (C, D) were measured in Jurkat (A, C) and K562 (B, D) cell lysates. In part A, β-actin was used as a loading control. Enzyme activity was expressed as nmole AMC released per minute per mg total cellular protein. The graphs show the average ±s.d. of three independent experiments.