Table 1. Somatic mutations of PIK3CA in cancer types reported since 10/2005.

Cancer	% PIK3CA mutationa	Sample source (primary tissue vs cancer cell line)	Exon mutated	Functional domain	Reference
Liver	35.6 (26/73)	Primary	9 and 20	Helical and kinase	Lee et al (2004)
Total liver 36% (26/73)
Breast	33.3 (4/12)	Cell lines	9 and 20	Helical and kinase	Bachman et al (2004)
Breast	21.4 (9/42)	Primary	1, 9 and 20	p85, helical and kinase	Bachman et al (2004)
Breast	18.1 (13/72)	Primary	9 and 20	Helical and kinase	Levine et al (2005)
Breast	40.0 (28/70)	Primary	6, 7, 9 and 20	C2, helical and kinase	Campbell et al (2004)
Breast	20.7 (19/92)	Primary	9 and 20	Helical and kinase	Wu et al (2005a)
Breast	8.3 (1/12)	Primary	20	kinase	Samuels et al (2004)
Breast	33.3 (5/15)	Cell lines	9 and 20	Helical and kinase	Wu et al (2005a)
Breast	26.9 (25/93)	Primary	9 and 20	Helical and kinase	Lee et al (2004)
Breast	28.0 (14/50)	Cell lines	1, 9 and 20	p85, helical and kinase	Saal et al (2005)
Breast	26.4 (77/292)	Primary	1, 4, 7, 9, 13, 18, 20	p85, C2, helical and kinase	Saal et al (2005)
Total breast 26% (195/750)
Colon	31.6 (74/234)	Primary	1, 2, 4, 7, 9, 18 and 20	P85, C2, helical and Kinase	Samuels et al (2004)
Colon	13.6 (14/103)	Primary	9 and 20	Helical and kinase	Velho et al (2005)
Colon	18.8 (6/32)	Primary	9 and 20	Helical and kinase	Campbell et al (2004)
Total colon 25% (94/369)
Ovarian	12.1 (24/198)	Primary	9 and 20	Helical and kinase	Levine et al (2005)
Ovarian	6.0 (11/182)	Primary	9 and 20	Helical and kinase	Campbell et al (2004)
Total ovarian 9% (35/380)
Gastric	25.0 (3/12)	Primary	18 and 20	Kinase	Samuels et al (2004)
Gastric	10.6 (5/47)	Primary	9 and 20	Helical and kinase	Velho et al (2005)
Gastric	6.5 (12/185)	Primary	9 and 20	Helical and kinase	Lee et al (2004)
Gastric	4.3 (4/94)	Primary	9 and 20	Helical and kinase	Li et al (2005)
Total gastric 7% (24/338)
Brain	26.7 (4/15)	Primary	4, 5 and 13	C2 and helical	Samuels et al (2004)
Brain	4.6 (13/285)	Primary	9 and 20	Helical and kinase	Broderick et al (2004)
Total brain 6% (17/300)
Lung	1.3 (3/229)	Primary	9 and 20	Helical and kinase	Lee et al (2004)
Lung	4.2 (1/24)	Primary	9	Helical	Samuels et al (2004)
Total lung 2% (4/253)
Leukaemia	1.1 (1/88)	Primary	9	Helical	Lee et al (2004)
Total leukaemia 1% (1/88)
Total cancers reported 15% (382/2551)

^aThe majority of PIK3CA documented mutations being somatic missense mutations, this table does not include other genetic changes (i.e. gene amplifications, deletions, insertions, etc.).