Table 2. Summary of those identified with abnormalities (patient may have more than one abnormality).
| Age at study (years) | Number of years of follow-up | Mantle radiation dose (Gy) (fractionation) | Cumulative dose of doxorubicin (mg m−2) | Thyroid abnormality | Echo abnormality | Lung defects |
|---|---|---|---|---|---|---|
| 50.1 | 25 | 35 (19) | Goitre | Major | Restrictive | |
| 30.7 | 12 | 38.5 (22) | 393.0 | Minor | Obstructive | |
| 34.7 | 17 | 35 (19) | 240.0 | Obstructive | ||
| 39.1 | 18 | 35 (20) | Reduced TLCO | |||
| 38.2 | 12 | 35 (20) | 330.0 | Restrictive | ||
| 47.4 | 21 | 35 (20) | Minor | |||
| 40.9 | 9 | 35 (20) | 183.0 | Reduced TLCO | ||
| 36.5 | 6 | 35 (20) | 204.0 | Reduced TLCO | ||
| 47.2 | 14 | 35 (20) | 360.0 | Raised TSH | ||
| 37.0 | 5 | 35 (20) | 240.0 | Minor | ||
| 46.7 | 17 | 35 (19) | 195.0 | Obstructive | ||
| 46.9 | 26 | 30 (19) | Minor | Obstructive | ||
| 52.6 | 35 | 35 (20) | Major | Obstructive | ||
| 41.4 | 7 | 35 (20) | 236.0 | Obstructive | ||
| 41.9 | 9 | 35 (20) | 284.0 | Minor | Obstructive | |
| 43.2 | 12 | 35 (20) | Obstructive | |||
| 36.3 | 9 | 35 (20) | 195.0 | Obstructive | ||
| 54.2 | 33 | 35 (20) | Major | Obstructive | ||
| 47.3 | 25 | 35 (20) | Minor | Obstructive | ||
| 53.4 | 29 | 37.5 (24) | Raised TSH | Reduced TLCO | ||
| 37.8 | 23 | 35 (19) | Restrictive | |||
| 38.6 | 21 | 35 (20) | Goitre | Minor | Restrictive | |
| 36.1 | 16 | 35 (20) | Reduced TLCO | |||
| 41.6 | 16 | 35 (20) | 270.0 | Major | ||
| 27.1 | 10 | 35 (20) | 225.0 | Restrictive | ||
| 56.9 | 36 | 27.4 (20) | Major | Restrictive | ||
| 53.6 | 27 | 35 (19) | Goitre | Major | ||
| 40.6 | 27 | 35 (18) | Goitre | |||
| 41.6 | 24 | 35 (19) | Goitre | |||
| 39.2 | 8 | 35 (20) | Reduced TLCO | |||
| 47.4 | 23 | 35 (19) | Major | Obstructive | ||
| 36.6 | 10 | 35 (20) | Reduced TLCO | |||
| 33.4 | 16 | 35 (20) | 480.0 | Minor | Reduced TLCO | |
| 34.5 | 10 | 36.75 (21) | Major | Reduced TLCO | ||
| 41.6 | 10 | 35 (20) | 480.0 | Raised TSH | Reduced TLCO | |
| 50.0 | 31 | 35 (20) | Goitre | Major | Obstructive | |
| 47.8 | 29 | 35 (20) | Minor | |||
| 42.5 | 24 | 35 (20) | Minor | Obstructive | ||
| 36.5 | 17 | 35 (20) | Reduced TLCO | |||
| 43.6 | 28 | 35 (19) | Reduced TLCO | |||
| 35.3 | 9 | 35 (20) | Raised TSH | |||
| 47.7 | 19 | 35 (19) | Major |
TSH=thyrotropin; TLCO=transfer factor.
Major cardiac abnormalities include: aortic valve disease, mitral regurgitation, mitral and aortic valve replacement and left ventricular impairment (EF<50%).
Minor cardiac abnormalities include: valve leaflet thickening, regional abnormality of LV wall, mild aortic or mitral valvular regurgitation.